Antibiotic Resistance Pattern of Pseudomonas aeruginosa Isolated from Clinical Samples in Ekiti State University Teaching Hospital, Ado-Ekiti, Ekiti State of Nigeria

Aims: To investigate the prevalence of acquired multidrug resistance of P. aeruginosa among clinical samples obtained from patients attending Ekiti State University Teaching Hospital, Ado Ekiti, Ekiti State, Nigeria.

Place and Duration of Study: Ekiti State Teaching Hospital from January-March 2013.

Methodology: The isolates were characterized by standard cultural and biochemical tests and they were tested for their sensitivity to different antibiotics using disk diffusion method.

Results: A total of 192 clinical samples were collected from which 42 isolates of P. aeruginosa were obtained. Antibiogram profile showed that a total of 80.95% of the isolates were resistant to ceftriaxone and ceftizoxime respectively, 76.2% to augmentin, 73.8% to ceftazidime, 71.4% to nitrofurantoin, 47.6% to ofloxacin, 45.23% to gentamicin while ciprofloxacin had the lowest resistance of 42.86. Isolates from ear swabs had the highest resistance to 3rd generation cephalosporins, followed by isolates from urine while isolates from wound samples showed the lowest resistance.

Conclusion: There is a need to institute an effective antimicrobial resistance surveillance system that provides clinicians with up-to-date data on the prevalence and resistance pattern of commonly encountered pathogens like P. aeruginosa especially as nosocomial infection is concerned.