JAK-2V617F Mutation in Acute Leukemia (South Egypt Experience)

Badrawy, Hosny and Ibrahim, Abeer (2013) JAK-2V617F Mutation in Acute Leukemia (South Egypt Experience). International Blood Research & Reviews, 2 (1). pp. 1-7. ISSN 23217219

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Abstract

Aim: To search for JAK2V617F mutation in patients with acute myeloid and acute lymphoblastic leukemia in south Egypt.

Study Design: JAK2V617F mutation detected by amplification refractory mutation system (ARMS) -PCR.

Place and Duration of Study: Department of clinical pathology and department of medical oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt, between December 2010 and December 2012.

Method: We included 90 patients (58 men and 32 women; age range 2-67 years) with denovo acute leukemia (30 acute myeloid leukemia and 60 acute lymphoblastic leukemia), JAK-2 V617F mutation using ARMS-PCR was done for all the patients.

Results: JAK-2 V617F mutation was absent in all of the studied patients.

Conclusion: Our results confirm the finding published previously which reported that JAK2 V617F mutation is very rare or absent in acute leukemia.

Item Type: Article
Subjects: STM Digital Library > Medical Science
Depositing User: Unnamed user with email support@stmdigitallib.com
Date Deposited: 10 Jul 2023 05:15
Last Modified: 18 May 2024 07:45
URI: http://archive.scholarstm.com/id/eprint/1414

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