METHODS OF METABOLIC CORRECTION IN EXPERIMENTAL IMMEDIATE HYPERSENSITIVITY

In this paper presents an experimental study of the effect of biologically active supplementation with antioxidant complex composition, sodium dichloroacetate and water with reduced deuterium content in the development and course of an allergic reaction in ovalbumin immunized rats. The development of experimental immediate hypersensitivity accompanied by increase of total IgE production to 5,8 times, and the imbalance of the cytokine, with a predominance of Th2-cytokine and decreased activity of Th1-lymphocytes. The studied biologically active supplement has proved its antioxidant properties, when using it was observed activation of catalase and glutathionereductase in ovalbumin-immunized rats but positive effect on cytokine and immunoglobulin status is not provided. Rats injections of sodium dichloroacetate and water with reduced deuterium content have an immunomodulatory effects that canceled imbalance of IL4/IFNγ relation with the normalization of IgE production. This is significant for possibility of correction of immunological disturbances in atopy by targeted displacement Th1 / Th2 balance using immunomodulator pathogenesis action.