The Relation between Biochemical Parameters and Rheumatoid Arthritis Disease

Aims: Rheumatoid arthritis is a self-immunity, progressive, and chronic disease the cause of which is still not clear. This disorder is mainly characterized with non-exclusive inflammation of local joints or joints inflammation, morning stiffness, destruction of articular tissues, and transformation of joints. Studies have shown that development of rheumatoid arthritis is related to increased production of oxygen reactant species and decreased the ability to suppress oxidative stress. In rheumatoid arthritis patients, increased free radicals of oxygen (ROS) act as mediators of tissue damage. This point emphasizes on the necessity of applying appropriate methods for examining tissue oxidative condition and antioxidant compounds capabilities in patients with rheumatoid arthritis.

Methodology: We considered its relation with biochemical parameters. In surveying 130 patients with rheumatoid arthritis, the index rate of oxidant was compared in test group and control group using independent T Test by prooxidant-antioxidant balance (PAB).

Conclusion: Due to the fact that P Value <0. 001, we observed a meaningful difference with rheumatoid arthritis. In examining biochemical parameters in patients with rheumatoid arthritis, urea and has decreased while uric acid content has increased.