Khabaz, Mohamad Nidal and Abdelrahman, Amer Shafei and Al-Maghrabi, Jaudah Ahmad (2019) Expression of p-AMPK in colorectal cancer revealed substantial diverse survival patterns: Expression of p-AMPK in colorectal cancer. Pakistan Journal of Medical Sciences, 35 (3). pp. 685-690. ISSN 1682-024X
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Abstract
Objective: Several cancers have showed differences in the role of p- AMPK in cancer growth, progression and prognosis, and little is identified regarding the significance of p-AMPK expression in colorectal adenocarcinoma. Therefore, this report will define p-AMPK phenotype in a panel of colorectal carcinomas and explore the relationship between this phenotype and tumor clinicopathological features.
Methods: A total of 228 cases comprising 155 large intestine cancers and 73 controls (40 benign tumors and thirty three non-cancerous tissues) were employed in tissue microarray construction. Immunohistochemistry (IHC) staining was applied to reveal p-AMPK expression. This study was carried out in the pathology lab of King Abdulaziz University Hospital over a duration of 15 months and was completed on 7th July 2018.
Results: Phosphorylated AMPK was identified in 133 (85.8%) of colorectal cancers and 73 (100%) control cases. Histologic type was noticeably correlated with p-AMPK immunostaining (P= 0.001), high score of p-AMPK immunostaining is more frequent in control cases. Considerable varied survival models were observed with neoplasm size, metastatic tumor, recurrence and disease relapse (P-values <0.01). Survival estimates are considerably healthier in positive cases which have one of the following features size less than 5 cm, absence of metastatic tumor, no reoccurrence or disease relapse.
Conclusions: The present study showed a reduction in the IHC staining of p-AMPK in colorectal cancer compared with controls. IHC staining of p-AMPK can be a supportive marker in predicting prognosis and survival estimates of colorectal tumors with specific clinical factors.
Item Type: | Article |
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Subjects: | STM Digital Library > Medical Science |
Depositing User: | Unnamed user with email support@stmdigitallib.com |
Date Deposited: | 26 Apr 2023 05:40 |
Last Modified: | 14 Sep 2024 03:56 |
URI: | http://archive.scholarstm.com/id/eprint/975 |